Un ultimo estudio sobre Lyrica en Fibromialgia ha llegado a la conclusión de que el efecto de Lyrica en el dolor no depende de el estado de ansiedad o sintomas depresivos; por lo que gran parte de la reducción del dolor parece ser independiente de las mejoras en los síntomas de ansiedad o del estado de ánimo.
Edición | fibromialgia.nom.es 28-11-2007
The Effect of Anxiety and Depression on Improvements in Pain in a Randomized, Controlled Trial of Pregabalin for Treatment of Fibromyalgia
# Lesley M. Arnold, MD,**Women’s Health Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio; Lesley M. Arnold, MD, 222 Piedmont Avenue, Suite 8200, Cincinnati, OH 45219, USA. Tel: 513-475-8110; Fax: 513-475-8112; E-mail: Lesley.Arnold@uc.edu.
# Leslie J. Crofford, MD,††Division of Rheumatology & Women’s Health, Department of Internal Medicine, University of Kentucky, Lexington, Kentucky;
# Susan A. Martin, MSPH,‡‡Pfizer Global Research and Development, Ann Arbor, Michigan, USA
# James P. Young, MS,‡‡Pfizer Global Research and Development, Ann Arbor, Michigan, USA and
# Uma Sharma, PhD
ABSTRACT
Objective. To assess symptoms of anxiety and depression in a large cohort of fibromyalgia patients and to determine the impact of these symptoms on response of pain to pregabalin treatment.
Design. Patients completed the Hospital Anxiety and Depression Scale at the baseline visit in a randomized, controlled trial of pregabalin for treatment of fibromyalgia. Mean anxiety and depression subscale scores were calculated, and proportions of patients by symptom severity were determined. The difference between the proportion of patients reporting anxiety and depression at baseline was tested using McNemar’s test. Baseline anxiety and depression were evaluated as covariates by including them—as interaction terms with treatment—in an ancova model. A path analysis evaluated the association between improvements in anxiety and depression and pain relief.
Results. In total, 529 patients were enrolled. Significantly more patients reported anxiety symptoms (71%) than depressive symptoms (56%) (P < size="2"> Lesley M. Arnold MD, Leslie J. Crofford MD, Susan A. Martin MSPH, James P. Young MS, Uma Sharma PhD (2007)
The Effect of Anxiety and Depression on Improvements in Pain in a Randomized, Controlled Trial of Pregabalin for Treatment of Fibromyalgia
Pain Medicine 8 (8), 633–638. doi:10.1111/j.1526-4637.2007.00332.x
Objective. To assess symptoms of anxiety and depression in a large cohort of fibromyalgia patients and to determine the impact of these symptoms on response of pain to pregabalin treatment.
Design. Patients completed the Hospital Anxiety and Depression Scale at the baseline visit in a randomized, controlled trial of pregabalin for treatment of fibromyalgia. Mean anxiety and depression subscale scores were calculated, and proportions of patients by symptom severity were determined. The difference between the proportion of patients reporting anxiety and depression at baseline was tested using McNemar’s test. Baseline anxiety and depression were evaluated as covariates by including them—as interaction terms with treatment—in an ancova model. A path analysis evaluated the association between improvements in anxiety and depression and pain relief.
Results. In total, 529 patients were enrolled. Significantly more patients reported anxiety symptoms (71%) than depressive symptoms (56%) (P < size="2"> Lesley M. Arnold MD, Leslie J. Crofford MD, Susan A. Martin MSPH, James P. Young MS, Uma Sharma PhD (2007)
The Effect of Anxiety and Depression on Improvements in Pain in a Randomized, Controlled Trial of Pregabalin for Treatment of Fibromyalgia
Pain Medicine 8 (8), 633–638. doi:10.1111/j.1526-4637.2007.00332.x
fibromialgia
sindrome fatiga cronica
sindrome+quimico+multiple
dolor cronico
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