Se siguen sucediendo hallazgos sobre el mecanismo de nuestra enfermedad; todos estos estudios son presentados en las más prestigiosas revistas médicas y el tiempo llevará a resolver los enigmas de los mecanismos de nuestra enfermedad
Edición | Fibromialgia.nom.es 4-1-2008
Fuente | Scand J Rheumatol 2007 Nov-Dec; 36(6):470-7
El diario Escandinavo de reumatología recoge en un reciente estudio en el que se llega a la siguiente conclusión; La concentración urinaria de CTX-II y CTX-I baja y los niveles normales de Pyd y Dpd se encontraron en FM, pero su relación con la intensidad de los síntomas de la enfermedad de fibromialgiano es claro.
Para los profesionales que estén interesados en su lectura integra se reproduce el articulo original en Inglés a continuación;
Urinary markers of altered collagen metabolism in fibromyalgia patients
Ribel-Madsen S, Christgau S, Gronemann ST, Bartels EM, Danneskiold-Samsøe B, Bliddal H
Scand J Rheumatol 2007 Nov-Dec; 36(6):470-7.
Abstract Objective: To assess the metabolism of collagen in fibromyalgia (FM) patients, and to compare the occurrence of collagen metabolism markers to the severity of FM symptoms.
Methods: Morning urine was collected from 27 FM women fulfilling the American College of Rheumatology (ACR) criteria for FM, and from seven controls. FM patients completed the Fibromyalgia Impact Questionnaire (FIQ). Bone mineral density (BMD), isokinetic muscle strength in knee and elbow, and hand-grip strength were measured. Urinary concentrations of collagen type I cross-linked C-telopeptide (CTX-I) and collagen type II cross-linked C-telopeptide (CTX-II) were determined by enzyme-linked immunosorbent assay (ELISA). Pyridinoline (Pyd) and deoxypyridinoline (Dpd) were determined by liquid chromatography, and hydroxyproline (Hyp) by spectrophotometry. All concentration data were normalized to creatinine.
Results: Mean values in the FM group and the control group, respectively, were: urinary CTX-I 246.8 and 337.5 microg/mmol (p = 0.060); CTX-II 110.4 and 185.1 ng/mmol (p = 0.035); Pyd 56.1 and 52.3 nmol/mmol (NS); Dpd 15.1 and 14.0 nmol/mmol (NS); Pyd : Dpd ratio 4.05 and 3.96 (NS); Hyp 26.1 and 21.1 micromol/mmol (NS). Significant inverse correlations were seen between CTX-I and the intensity of fatigue, and between CTX-II and anxiety. An inverse correlation between CTX-I and muscle strength was apparent, but relied on extreme values from one patient, and no significant correlation was found between CTX-I or CTX-II and tender points or BMD in the FM group.
Conclusions: Low urinary concentrations of CTX-II and CTX-I and normal levels of Pyd and Dpd were found in FM, but their relationship to the intensity of FM symptoms was unclear.
Edición | Fibromialgia.nom.es 4-1-2008
Fuente | Scand J Rheumatol 2007 Nov-Dec; 36(6):470-7
El diario Escandinavo de reumatología recoge en un reciente estudio en el que se llega a la siguiente conclusión; La concentración urinaria de CTX-II y CTX-I baja y los niveles normales de Pyd y Dpd se encontraron en FM, pero su relación con la intensidad de los síntomas de la enfermedad de fibromialgiano es claro.
Para los profesionales que estén interesados en su lectura integra se reproduce el articulo original en Inglés a continuación;
Urinary markers of altered collagen metabolism in fibromyalgia patients
Ribel-Madsen S, Christgau S, Gronemann ST, Bartels EM, Danneskiold-Samsøe B, Bliddal H
Scand J Rheumatol 2007 Nov-Dec; 36(6):470-7.
Abstract Objective: To assess the metabolism of collagen in fibromyalgia (FM) patients, and to compare the occurrence of collagen metabolism markers to the severity of FM symptoms.
Methods: Morning urine was collected from 27 FM women fulfilling the American College of Rheumatology (ACR) criteria for FM, and from seven controls. FM patients completed the Fibromyalgia Impact Questionnaire (FIQ). Bone mineral density (BMD), isokinetic muscle strength in knee and elbow, and hand-grip strength were measured. Urinary concentrations of collagen type I cross-linked C-telopeptide (CTX-I) and collagen type II cross-linked C-telopeptide (CTX-II) were determined by enzyme-linked immunosorbent assay (ELISA). Pyridinoline (Pyd) and deoxypyridinoline (Dpd) were determined by liquid chromatography, and hydroxyproline (Hyp) by spectrophotometry. All concentration data were normalized to creatinine.
Results: Mean values in the FM group and the control group, respectively, were: urinary CTX-I 246.8 and 337.5 microg/mmol (p = 0.060); CTX-II 110.4 and 185.1 ng/mmol (p = 0.035); Pyd 56.1 and 52.3 nmol/mmol (NS); Dpd 15.1 and 14.0 nmol/mmol (NS); Pyd : Dpd ratio 4.05 and 3.96 (NS); Hyp 26.1 and 21.1 micromol/mmol (NS). Significant inverse correlations were seen between CTX-I and the intensity of fatigue, and between CTX-II and anxiety. An inverse correlation between CTX-I and muscle strength was apparent, but relied on extreme values from one patient, and no significant correlation was found between CTX-I or CTX-II and tender points or BMD in the FM group.
Conclusions: Low urinary concentrations of CTX-II and CTX-I and normal levels of Pyd and Dpd were found in FM, but their relationship to the intensity of FM symptoms was unclear.
PubMed ID18092271
fibromialgia
sindrome fatiga cronica
sindrome+quimico+multiple
dolor cronico
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